Characteristics of changes in the structural components of the mucosa and rat laryngeal cartilage at the end of the third week of experimental opioid exposure

In our work we aimed to study the pathomorphological manifestations among structural components of laryngeal mucosa and cartilage in early stages experimental opioid effect. This goal was achieved through use histological techniques visualize cartilage. Histological sections with a thickness 5 - 7 mm were made. specimens prepared according conventional methods using dye hematoxylin, eosin, azan method Heidenhain, PAS-reaction Mc-Manus Alcian blue Steedman. Microscopic examinations photographing preparations performed an MBI-1 microscope Nicon D 3100 digital camera.At microstructural level after 21 days rats there increase dyscirculatory changes, which most pronounced vessels lamina propria mucosa. The epithelial layer epiglottis inhomogeneously thickened, especially on pharyngeal surface. Small polymorphonuclear infiltrates found epiglottis. ventricular larynx dilated filled erythrocytes. development perivascular edema registered. areas transudate accumulation, main substance enlightened. Necrotic changes developed epitheliocytes ventricle. Eosinophilic mass accumulated surface mucosa.The results future will form base that can be used for comparative characterization dynamics growth compare these late exposure.